Cape Girardeau County ...Sheffield is located in Cape Girardeau County<1>. The following counties adjoin and form the boundaries of Cape Girardeau County: Alexander (IL), Union (IL), Bollinger, Perry, Scott & Stoddard. The Mississippi River runs along the eastern border of the county. Websites We Enjoy ...When we're planning a trip, we like to check the following websites for sights, attractions and places to visit.
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