Welcome to Issaquena County ...Time Zone: Issaquena County lies in the Central Time Zone (CST/CDT) and observes daylight saving time. The community of Mayersville is the Seat for Issaquena County. Issaquena County was founded in 1844 and was created by taking area from Washington County. From the Census Estimates for 2019, <1> Issaquena had a population of 1,327 people. This is a decrease of 4.26% since the last Census (which gave a population of 1,386 people in 2010). At the time of the 2010 Census, Issaquena represented 0.05% of the total population of Mississippi. Websites of Interest ...
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